Meryl Streep
Kay

Tommy Lee Jones
Arnold Soames

Steve Carell
Dr. Bernie Feld

Jean Smart
Eileen, Kay's Friend

Marin Ireland
Molly, Their Daughter

Ben Rappaport
Brad, Their Son

Brett Rice
Vince, Arnold's Friend

Becky Ann Baker
Cora, The Waitress

Elisabeth Shue
Karen, The Bartender

Charles Techman
Charlie, The Docent

Danny Flaherty
Danny, The Bookstore Clerk

Damian Young
Mike, The Innkeeper

Mimi Rogers
Carol, The Neighbor

Ann Harada
Ann

Jack Haley
Jack, The Happy Husband

Patch Darragh
Mark, Their Son-in-Law

Susan Misner
Dana, Doctor Feld's Wife

Madeline Ruskin
Maddie, Brad's Girlfriend

Paul Jude Letersky
Paul, The Unhappy Husband

John Franchi
Driver (uncredited)