Tom Hiddleston
Charles 'Chuck' Krantz

Jacob Tremblay
Charles 'Chuck' Krantz (teen)

Benjamin Pajak
Charles 'Chuck' Krantz (pre-teen)

Nick Offerman
Narrator (voice)

Chiwetel Ejiofor
Marty Anderson

Karen Gillan
Felicia Gordon

Annalise Basso
Janice Halliday

Mia Sara
Sarah Krantz

Mark Hamill
Albie Krantz

Samantha Sloyan
Miss Rohrbacher

Trinity Bliss
Cat McCoy

David Dastmalchian
Josh

Matthew Lillard
Gus

Kate Siegel
Miss Richards

Rahul Kohli
Bri

Harvey Guillén
Hector

Saidah Arrika Ekulona
Andrea

Carl Lumbly
Sam Yarbrough

Michael Trucco
Dylan's Dad

Q'orianka Kilcher
Virginia 'Ginny' Krantz

Violet McGraw
Iris

Andrew Grush
Mac

Heather Langenkamp
Vera Stanley

Franklin Ritch
Brent

Antonio Raul Garcia
Brian Krantz

Molly C. Quinn
Chuck's Mother

Sauriyan Sapkota
Ram

Mike Flanagan
Mourner

Matt Biedel
Doctor Winston

Carla Gugino
News and Commercial Voice (voice)

Elan Gale
Radio News Reporter (voice)

Scott Wampler
Radio Host #2 (voice)

Hamish Linklater
American Reporter (voice)

Axelle Carolyn
French Reporter (voice)

Sandra Hess
German Reporter (voice)

Lauren LaVera
Italian Reporter (voice)

Trevor Macy
Mourner (uncredited)