Will Ferrell
Ron Burgundy

Christina Applegate
Veronica Corningstone

Paul Rudd
Brian Fantana

Steve Carell
Brick Tamland

David Koechner
Champ Kind

Fred Willard
Ed Harken

Chris Parnell
Garth Holliday

Kathryn Hahn
Helen

Fred Armisen
Tino

Seth Rogen
Eager Cameraman

Paul F. Tompkins
MC

Danny Trejo
Bartender

Scot Robinson
Waiter at Tino's

Ian Roberts
Stage Manager

Darcy Donavan
Hot Blonde

Renee Weldon
Petite Brunette

Jerry Minor
Tino's Bassist

Holmes Osborne
Director

Charles Walker
Security Guard

Shira Piven
Mother

Lili Rose McKay
Child

Jay Johnston
Eyewitness News Member

Peter A. Hulne
Man in Kitchen

Laura Kightlinger
Donna

Adam McKay
Custodian

Judd Apatow
News Station Employee

Debra McGuire
News Station Employee

Kent Shocknek
Network Reporter

Esmerelda McQuillan
Middle Class Mother

Lionel Allen
Wealthy Family Father

Trina D. Johnson
Wealthy Family Mother

Glen Hambly
Middle Class Dad

Bill Kurtis
Bill Lawson

Jack Black
Motorcyclist

Ben Stiller
Arturo Mendes

Luke Wilson
Frank Vitchard

Missi Pyle
Zoo Keeper (uncredited)

Tim Robbins
Public TV News Anchor (uncredited)

Vince Vaughn
Wes Mantooth (uncredited)

Jerry Stiller
Man in Bar (uncredited)

Matthew Vlahakis
Zoologist with Panda in Doug or Glen scene (uncredited)