Johnny Depp
William Blake

Gary Farmer
Nobody

Crispin Glover
Train Fireman

Lance Henriksen
Cole Wilson

Michael Wincott
Conway Twill

Eugene Byrd
Johnny 'The Kid' Pickett

John Hurt
John Scholfield

Robert Mitchum
John Dickinson

Iggy Pop
Salvatore 'Sally' Jenko

Gabriel Byrne
Charlie Dickinson

Jared Harris
Benmont Tench

Mili Avital
Thel Russell

Jimmie Ray Weeks
Marvin, Older Marshal

Mark Bringelson
Lee, Younger Marshal

Alfred Molina
Trading Post Missionary

Billy Bob Thornton
Big George Drakoulious

Michelle Thrush
Nobody's Girlfriend

Gibby Haynes
Man with Gun in Alley

Richard Boes
Man with Wrench