Humphrey Bogart
Samuel Spade

Mary Astor
Brigid O'Shaughnessy

Gladys George
Iva Archer

Peter Lorre
Joel Cairo

Barton MacLane
Lt. of Detectives Dundy

Lee Patrick
Effie Perine

Sydney Greenstreet
Kasper Gutman

Ward Bond
Det. Tom Polhaus

Jerome Cowan
Miles Archer

Elisha Cook Jr.
Wilmer Cook

James Burke
Luke

Murray Alper
Frank Richman

John Hamilton
District Attorney Bryan

Charles Drake
Reporter (uncredited)

Chester Gan
Bit Part (uncredited)

Creighton Hale
Stenographer (uncredited)

Robert Homans
Policeman (uncredited)

William Hopper
Reporter (uncredited)

Walter Huston
Captain Jacoby (uncredited)

Hank Mann
Reporter (uncredited)

Jack Mower
Announcer (uncredited)

Emory Parnell
Ship's Mate (uncredited)