E. G. Daily
Tommy Pickles (voice)

Nancy Cartwright
Chuckie Finster (voice)

Cheryl Chase
Angelica Pickles (voice)

Cree Summer
Susie Carmichael (voice)

Kath Soucie
Phil DeVille / Lil DeVille (voice)

Ashley Rae Spillers
Didi Pickles (voice)

Tommy Dewey
Stu Pickles (voice)

Tony Hale
Chas Finster (voice)

Natalie Morales
Betty DeVille (voice)

Anna Chlumsky
Charlotte Pickles (voice)

Timothy Simons
Drew Pickles (voice)

Nicole Byer
Lucy Carmichael (voice)

Omar Benson Miller
Randy Carmichael (voice)

Michael McKean
Grandpa Lou Pickles (voice)