Bill Burr
Frank Murphy (voice)

Laura Dern
Sue Murphy (voice)

Justin Long
Kevin Murphy (voice)

Haley Reinhart
Bill Murphy (voice)

Debi Derryberry
Maureen Murphy / Bridget Fitzsimmons / Phillip Bonfiglio (voice)

Sam Rockwell
Vic (voice)

David Koechner
Bob Pogo (voice)

Kevin Michael Richardson
Rosie Roosevelt (voice)

Trevor Devall
Otto Holtenwasser / Goomer / Bolo (voice)

Mo Collins
Vivian Saunders / Lex / Ginny Throater / Nana Rose (voice)

Kevin Farley
Babe Bonfiglio (voice)

Phil Hendrie
Jim Jeffords (voice)