Karl Urban
Billy Butcher

Jack Quaid
Hugh 'Hughie' Campbell

Antony Starr
John / Homelander

Erin Moriarty
Annie January / Starlight

Jessie T. Usher
Reggie Franklin / A-Train

Laz Alonso
Marvin T. 'Mother's Milk' Milk / M.M.

Chace Crawford
Kevin Moskowitz / The Deep

Tomer Capone
Serge / Frenchie

Karen Fukuhara
Kimiko Miyashiro / The Female

Nathan Mitchell
Black Noir II

Colby Minifie
Ashley Barrett

Claudia Doumit
Victoria 'Vic' Neuman

Cameron Crovetti
Ryan

Susan Heyward
Jessica Bradley / Sister Sage

Valorie Curry
Misty Tucker Gray / Firecracker

Jeffrey Dean Morgan
Joe Kessler