Steve Zahn
Wayne Lefessier

Jack Black
J.D. McNugent

Jason Biggs
Darren Silverman

Amanda Peet
Judith Fessbeggler

Amanda Detmer
Sandy

R. Lee Ermey
Coach

Neil Diamond
Self

Kyle Gass
Bar Dude

Andrew McIlroy
Waiter

Colin Foo
Old Man

Christopher Logan
Vageet

Oscar Goncalves
Man

Lillian Carlson
Mother Superior

Mark Aaron Wagner
Luigi

Stephen Chang
Thai Referee

Eliza Norbury
Wayne's Mom

Michael Roberds
Doctor

Sean Owen Roberts
Wong

Ken Camroux-Taylor
Warren

Odessa Munroe
Hooker

Tracy Trueman
Hooker

Devin Douglas Drewitz
Young Wayne

Carly McKillip
Cute Girl

Carla Boudreau
Beautiful Woman

Biski Gugushe
Cop At Darren's House

Steven McMichael
Josh

Dennis Dugan
Referee

Larry Lam
Thai Kickboxer

Brett Armstrong
Brett