Chevy Chase
Clark Griswold

Beverly D'Angelo
Ellen Griswold

Anthony Michael Hall
Rusty Griswold

Imogene Coca
Aunt Edna

Randy Quaid
Cousin Eddie

Dana Barron
Audrey Griswold

Eddie Bracken
Roy Walley

Brian Doyle-Murray
Kamp Komfort Clerk

Miriam Flynn
Cousin Catherine

James Keach
Motorcycle Cop

Eugene Levy
Car Salesman

Frank McRae
Grover

John Candy
Lasky, Guard at Walleyworld

Christie Brinkley
Girl In The Red Ferrari

Jane Krakowski
Cousin Vicki

John P. Navin, Jr.
Cousin Dale

Nathan Cook
Man Giving Directions

Mickey Jones
Mechanic

John Diehl
Assistant Mechanic

Randy Lowell
Wyatt Earp

Gerry Black
Davenport

James Staley
Motel Desk Clerk

Tessa Richarde
Motel Guest

Fritz Ford
Neighbor

Michael Talbott
Cowboy

Henry Gibson
Hotel clerk (uncredited)

Harold Ramis
Car salesman (voice) (uncredited)