Jennifer Aniston
Rose O'Reilly

Jason Sudeikis
David Clark

Emma Roberts
Casey Mathis

Will Poulter
Kenny Rossmore

Ed Helms
Brad Gurdlinger

Nick Offerman
Don Fitzgerald

Kathryn Hahn
Edie Fitzgerald

Molly C. Quinn
Melissa Fitzgerald

Tomer Sisley
Pablo Chacon

Matthew Willig
One-Eye

Luis Guzmán
Mexican Cop

Thomas Lennon
Rick Nathanson

Mark L. Young
Scottie P.

Ken Marino
Todd - Strip Club Owner

Laura-Leigh
Kymberly

Crystal Nichol
Brad's Receptionist

D.A. Obahor
Parking Cop

Brett Gentile
White Bread Dad

Kelly Collins Lintz
White Bread Mom

Sam Richardson
TSA Agent

Lynn Talley
Stylist

Alan Gilmer
Middle Aged Man

Denielle Fisher Johnson
Flight Attendant #1

Deborah Chavez
Flight Attendant #2

Kevin Dorff
Border Guard #1

Rawson Marshall Thurber
The Ultimate Border Guard

Dave McElhaney
White Gringo

Brendan Hunt
Sketchy Dude

Scott Adsit
Doctor

Vickie Eng
Hospital Nurse

Lunden De'Leon
Hospital Receptionist

Joey Nappo
Gutter Punk #1

Joshua Mikel
Gutter Punk #2

Matt Schweppe
Gutter Punk #3

Tonya Bludsworth
Soccer Mom

Matthew Cornwell
Dan Johnson

Marcus Viscidi
Business Man

Loren Anthony
Mexican Border Crosser (uncredited)

Joshua R. Aragon
Drug Cartel Member (uncredited)

Lionel Archuleta
Mexican Pedestrian (uncredited)

Jenique Bennett
Stripper (uncredited)

Ashley Blankenship
Hot Tub Bikini Girlfriend (uncredited)

Robert Crayton
Kidnapper (uncredited)

Lindsay Davis
Hot Tub Girlfriend (uncredited)

Tait Fletcher
Creepy Trucker (uncredited)

William Frasca
Pedestrian (uncredited)

Lawrence Gilligan
Border Guard (uncredited)

Natalia Marie
Stripper (uncredited)

John Henry Scott
Stilt Walker (uncredited)