Adam Sandler
George Simmons

Seth Rogen
Ira Wright

Leslie Mann
Laura

Eric Bana
Clarke

Jonah Hill
Leo Koenig

Jason Schwartzman
Mark Taylor Jackson

Aubrey Plaza
Daisy Danby

RZA
Chuck

Aziz Ansari
Randy

Maude Apatow
Mable

Iris Apatow
Ingrid

Torsten Voges
Dr. Lars

Allan Wasserman
Dr. Stevens

Rod Man
Rod Man

Wayne Federman
Comedy & Magic Manager

Mike O'Connell
MySpace Escort

James Taylor
James Taylor

Nicole Parker
Dawn

Nydia McFadden
Mandy

Andy Dick
Andy Dick

Charles Fleischer
Charles Fleischer

Nicol Paone
George's Sister

George Coe
George's Dad

Budd Friedman
Budd Friedman

Monty Hoffman
Monty Hoffman

Carol Leifer
Carol Leifer

Paul Reiser
Paul Reiser

Mark Schiff
Mark Schiff

George Wallace
George Wallace

Norm Macdonald
Norm Macdonald

Dave Attell
Dave Attell

Sarah Silverman
Sarah Silverman

Bryan Batt
George's Agent

Maggie Siff
Rachel

Eminem
Eminem

Ray Romano
Ray Romano

Jon Brion
Jon Brion

James Gadson
James Gadson

Bo Burnham
Yo Teach Cast Member

Miki Ishikawa
Yo Teach Cast Member

Kenny Copeland Jr.
Yo Teach Cast Member

Calvin Sykes
Yo Teach Cast Member

Ca'Shawn Sims
Yo Teach Cast Member

Phillip Andre Botello
Yo Teach Cast Member

Carla Gallo
Miss Pruitt on Yo Teach

Ernest Lee Thomas
Yo Teach Principal

Tonita Castro
Bonita

Steve Bannos
Deli Manager

Justin Long
Re-Do Guy

Lucas Astrom
College Guy with Camera

Tyler Spindel
College Guy with Camera

Elaine Kao
Mom with Camera

King Kedar
Family with Camera

Tanya Acker
Family with Camera

Jarrett Grode
Magician

Qiana Chase
Chuck's Wife

John Hartmann
Private Jet Pilot

Dave Rath
San Francisco Theatre Manager

Dan Harmon
Paparazzi at Medical Center

Kyle Kinane
Paparazzi at Medical Center

Mark Cohen
Emcee at Improv

Joanie Marx
Deli Customer

Adam J. Bernstein
Hot Dog-Eating Champion's Son

Da'Vone McDonald
Hot Dog-Eating Co-Star

Orny Adams
Orny Adams

Al Lubel
Al Lubel

Jerry Minor
Jerry Minor

Eleanor Zee
George's Mom

Ben Meyerson
George's Brother-In-Law

Sammy Jack
George's Young Nephew

Andrea Zonn
Andrea Zonn

Kate Markowitz
Kate Markowitz

Arnold McCuller
Arnold McCuller

Luis Conte
Luis Conte

Russ Kunkel
Russ Kunkel

Brian Lally
Comedy & Magic Club Audience

Jimmy Johnson
Jimmy Johnson

Janeane Garofalo
Friend in video (archive footage) (uncredited)

Ben Stiller
Friend in video (archive footage) (uncredited)

Judd Apatow
Friend in video (voice) (archive footage) (uncredited)