Clint Eastwood
Blondie

Eli Wallach
Tuco Ramirez

Lee Van Cleef
Sentenza / Angel Eyes

Aldo Giuffrè
Alcoholic Union Captain

Luigi Pistilli
Father Pablo Ramirez

Rada Rassimov
Maria

Enzo Petito
Storekeeper

Claudio Scarchilli
Tuco Henchman

Antonio Casale
Bill Carson / Jackson

Livio Lorenzon
Baker

Sandro Scarchilli
Tuco Henchman

Benito Stefanelli
Member of Angel Eyes' Gang

Antonio Casas
Stevens

Aldo Sambrell
Member of Angel Eyes' Gang

Al Mulock
One-Armed Bounty Hunter

Sergio Mendizábal
Blonde Bounty Hunter

Antonio Molino Rojo
Captain Harper

Lorenzo Robledo
Clem

Mario Brega
Corporal Wallace

Chelo Alonso
Stevens' Wife (uncredited)

Fortunato Arena
1st Sombrero Onlooker at Tuco's 1st Hanging (uncredited)

Román Ariznavarreta
Bounty Hunter (uncredited)

Silvana Bacci
Mexican Woman with Blondie (uncredited)

Frank Braña
Bounty Hunter #2 (uncredited)

Amerigo Castrighella
2nd Sombrero Onlooker at Tuco's 1st Hanging (uncredited)

Saturno Cerra
Bounty Hunter (uncredited)

Tony Di Mitri
Deputy (uncredited)

Gianni Di Segni
Deputy at 1st Hanging (uncredited)

Alberigo Donadeo
Spectator Before Hanging (uncredited)

Attilio Dottesio
3rd Sombrero Onlooker at Tuco's 1st Hanging (uncredited)

Luis Fernández de Eribe
Soldier Coat (uncredited)

Veriano Ginesi
Bald Onlooker at Tuco's 1st Hanging (uncredited)

Jesús Guzmán
Pardue the Hotel Owner (uncredited)

Víctor Israel
Sergeant at Confederate Fort (uncredited)

Nazzareno Natale
Mexican Bounty Hunter (uncredited)

Ricardo Palacios
Barista a Socorro (uncredited)

Romano Puppo
Member of Angel Eyes' Gang (uncredited)

Antoñito Ruiz
Stevens' Youngest Son (uncredited)

Aysanoa Runachagua
Pistolero Recruited by Tuco in the Cave (uncredited)

José Terrón
Thomas 'Shorty' Larson (uncredited)

Antonio Montoya
Mexican Bounty Hunter (uncredited)