Yahya Abdul-Mateen II
Anthony McCoy

Teyonah Parris
Brianna Cartwright

Colman Domingo
William Burke

Nathan Stewart-Jarrett
Troy Cartwright

Kyle Kaminsky
Grady Smith

Vanessa Williams
Anne-Marie McCoy

Brian King
Clive Privler

Miriam Moss
Jerrika

Rebecca Spence
Finley Stephens

Carl Clemons-Hopkins
Jameson

Christiana Clark
Danielle Harrington

Michael Hargrove
Candyman / Sherman Fields

Rodney L Jones III
Billy

Ireon Roach
Trina

Breanna Lind
Annika

Heidi Grace Engerman
Haley Gulick

Sarah Lo
Samantha

Ro White
Boof

Torrey Hanson
Jack Hyde

Cassie Kramer
Librarian

Sarah Wisterman
Celine

Cedric Mays
Gil Cartwright

Hannah Love Jones
Young Brianna

J. Nicole Brooks
Dr. Collins

Genesis Denise Hale
Sabrina

Tien Tran
Jane Ji

Aaron Crippen
Police Officer Smith

Nadia Simms
Ringleader

Nancy Pender
TV News Anchor

Tony Todd
Candyman / Daniel Robitaille

Virginia Madsen
Helen Lyle (voice)

Ben Marten
Officer Cooke (uncredited)