Annabelle Wallis
Madison Mitchell

Maddie Hasson
Sydney Lake

George Young
Detective Kekoa Shaw

Michole Briana White
Detective Regina Moss

Susanna Thompson
Jeanne

Ingrid Bisu
Winnie

Jean Louisa Kelly
Jane Doe

Jake Abel
Derek Mitchell

Jacqueline McKenzie
Dr. Florence Weaver

Christian Clemenson
Dr. Victor Fields

Amir Aboulela
Dr. Gregory

Mercedes Colon
Mendez

Ruben Pla
Officer Rubin

Jon Lee Brody
Officer Lee

Paula Marshall
Beverly Woods

Zoë Bell
Scorpion

Natalia Safran
Nurse Annie

Mike Mendez
Hospital Security Guard #1

Lisa Catara
Research Orderly

Danielle Nottingham
News Anchor

Ray Chase
Gabriel (voice)

Marina Mazepa
Gabriel

Mckenna Grace
Young Madison

Madison Wolfe
Young Serena

Andy Bean
Frank

Patricia Velásquez
Nurse Velasquez

Patrick Cox
Mr. Stanley (uncredited)

Janet Hsieh
Nurse J. De Marco (uncredited)

Paul Mabon
Orderly (uncredited)

Gino Montesinos
Seattle Police Officer (uncredited)

Kalina Vanska
Seattle Police Officer (uncredited)

Christina Veronica
Prisoner (uncredited)

Rachel Winfree
Mrs. Ryerson (uncredited)