Seth MacFarlane
Stewie Griffin / Various Characters (voice)

Alex Borstein
Lois Griffin / Various Characters (voice)

Seth Green
Chris Griffin / Various Characters (voice)

Mila Kunis
Meg Griffin / Various Characters (voice)

Patrick Warburton
Joe Swanson (voice)

Lori Alan
Diane Simmons (voice)

Drew Barrymore
Drew Barrymore (voice)

Mike Henry
Cleveland Brown / John Herbert (voice)

Rachael MacFarlane
Katie Couric / Baby-Expecting Woman / Britney Spears (voice)

Noel Blanc
Elmer Fudd (voice)

Phil LaMarr
Ollie Williams /Various Characters (voice)

John G. Brennan
Horace / Additional Voices (voice)

Gary Janetti
Various Characters (voice)

Don LaFontaine
Promo Announcer (voice)

Ron Livingston
Clerk (voice)

Kevin Michael Richardson
Ray Charles / Various Characters (voice)

Kate Rigg
Various Characters (voice)

Will Sasso
Randy Newman / James Lipton (voice)

André Sogliuzzo
Various Characters (voice)

Rory Thost
Casper (voice)

John Viener
Meg 'Ron' Griffin (voice)

Adam West
Mayor Adam West (voice)

Wally Wingert
Various Characters (voice)

René Auberjonois
Odo (voice)

Ali Hillis
Meg Griffin (singing voice) / Various Characters (voice)

Ralph Garman
Various Characters (voice)

Jennie Garth
Kelly Taylor (voice)

Larry Kenney
Lion-O (voice)

Lynne Lipton
Cheetara (voice)

Jason Priestley
Brandon Walsh (voice)

Michael Clarke Duncan
The Stork (voice)

Tori Spelling
Donna Martin (voice)

Joy Behar
Joy Behar (voice)

Fred Tatasciore
Various Characters (voice)

Bill Fagerbakke
Indian (voice)

David A. Goodman
Jesus Christ (voice)

Busy Philipps
Various Characters (voice)

Audrey Wasilewski
Various Characters (voice)