George Clooney
Seth Gecko

Quentin Tarantino
Richard Gecko

Harvey Keitel
Jacob Fuller

Juliette Lewis
Kate Fuller

Ernest Liu
Scott Fuller

Salma Hayek Pinault
Santanico Pandemonium

Cheech Marin
Border Guard / Chet Pussy / Carlos

Danny Trejo
Razor Charlie

Tom Savini
Sex Machine

Fred Williamson
Frost

Michael Parks
Texas Ranger Earl McGraw

Brenda Hillhouse
Hostage Gloria

John Saxon
FBI Agent Stanley Chase

Marc Lawrence
Old Timer

Kelly Preston
Newscaster Kelly Houge

John Hawkes
Pete Bottoms

Tito Larriva
Titty Twister Guitarist & Vocalist

Peter Atanasoff
Titty Twister Saxophonist

Johnny Vatos Hernandez
Titty Twister Drummer

Aimee Graham
Blonde Hostage

Heidi McNeal
Red-headed Hostage

Ernest M. Garcia
Big Emilio

Greg Nicotero
Sex Machine's Buddy

Cristos
Danny

Mike Moroff
Manny

Michelle Berube
Bar Dancer

Rosalia Hayakawa
Bar Dancer

Neena Bidasha
Bar Dancer

Janine Jordae
Bar Dancer

Veena Bidasha
Bar Dancer

Ungela Brockman
Bar Dancer

Tiffany Granath
Bar Dancer

Tia Texada
Bar Dancer

Michael McKay
Monster

Jake McKinnon
Monster

Walter Phelan
Monster

Wayne Toth
Monster

Annette Harper
Bar Dancer

Lawrence Bender
Man in Diner (Uncredited)

Robert Rodriguez
Band Member (uncredited)