Uma Thurman
The Bride

Lucy Liu
O-Ren Ishii

Vivica A. Fox
Vernita Green

Daryl Hannah
Elle Driver

David Carradine
Bill

Michael Madsen
Budd

Julie Dreyfus
Sofie Fatale

Chiaki Kuriyama
Gogo Yubari

Sonny Chiba
Hattori Hanzo

Gordon Liu Chia-Hui
Johnny Mo

Michael Parks
Earl McGraw

Michael Bowen
Buck

Jun Kunimura
Boss Tanaka

Kenji Ohba
Bald Guy (Sushi Shop)

Yuki Kazamatsuri
Proprietor

James Parks
Edgar McGraw

Sakichi Sato
Charlie Brown

Jonathan Loughran
Trucker

Yoshiyuki Morishita
Tokyo Business Man

Tetsuro Shimaguchi
Crazy 88 #1 (Miki)

Kazuki Kitamura
Crazy 88 #2

Yoji Tanaka
Crazy 88 #3

Issey Takahashi
Crazy 88 #4

Sō Yamanaka
Crazy 88 #5

Juri Manase
Crazy 88 #6 (Girl)

Akaji Maro
Boss Ozawah

Goro Daimon
Boss Honda

Shun Sugata
Boss Benta

Zhang Jinzhan
Boss Orgami

Hu Xiaohui
Young 88 (Spanked Boy)

Ambrosia Kelley
Nikki Bell

Ronnie Yoshiko Fujiyama
The 5, 6, 7, 8's

Shu Lan Tuan
Okinawa Airline Ticket Agent

Ai Maeda
O-Ren (anime sequence) (voice)

Naomi Kusumi
Boss Matsumoto (anime sequence) (voice)

Hikaru Midorikawa
Pretty Riki (anime sequence) (voice)