Johnny Depp
Donnie Brasco / Joseph D. 'Joe' Pistone

Al Pacino
Benjamin 'Lefty' Ruggiero

Michael Madsen
Dominick 'Sonny Black' Napolitano

Bruno Kirby
Nicholas 'Nicky' Santora

James Russo
Paulie

Anne Heche
Maggie Pistone

Zeljko Ivanek
Tim Curley

Brian Tarantina
Bruno

Rocco Sisto
Richard 'Richie' Gazzo

Zach Grenier
Dr. Berger

Gerry Becker
Agent Dean Blandford FBI

Robert Miano
Alphonse 'Sonny Red' Indelicato

Paul Giamatti
FBI Technician

Gretchen Mol
Sonny's Girlfriend

Tim Blake Nelson
FBI Technician

Walt MacPherson
Sheriff

Ronnie Farer
Annette

Terry Serpico
Strip Club Owner

Tony Lip
Philip 'Philly Lucky' Giaccone

Val Avery
Santo Trafficante Jr.

Madison Arnold
Jilly

Katie Sagona
Daughter

Larry Romano
Tommy

James McCauley
FBI Agent

Andrew Parks
Hollman

Rocco Musacchia
Trafficante's Man

Denise Faye
Mob Girlfriend

Elaine del Valle
Mob Girlfriend

John Horton
FBI Director

Frank Pesce
Wiseguy

John Di Benedetto
Wiseguy

Tony Ray Rossi
Wiseguy

Gaetano LoGiudice
Wiseguy

Flint Beverage
Kings Court Cop (uncredited)

Teresa Giudice
Shocked Stripper (uncredited)

Jim Lavin
Arresting FBI Officer (uncredited)

Peter O'Hara
Passerby (uncredited)

Antone Pagán
Prison Guard for Pacino and Depp (uncredited)

Garry Pastore
Carmine Galante's Bodyguard

Dale Resteghini
Strip Club Patron (uncredited)

Elle Alexander
Mob Girlfriend

Frankie Cee
Civilian (uncredited)